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Volume 129, Issue 5, Pages (November 2005)

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Presentation on theme: "Volume 129, Issue 5, Pages (November 2005)"— Presentation transcript:

1 Volume 129, Issue 5, Pages 1437-1444 (November 2005)
Influence of Experimentally Induced Anxiety on Gastric Sensorimotor Function in Humans  Brecht Geeraerts, Joris Vandenberghe, Lukas Van Oudenhove, Lloyd J. Gregory, Quasim Aziz, Patrick DuPont, Koen Demyttenaere, Jozef Janssens, Jan Tack  Gastroenterology  Volume 129, Issue 5, Pages (November 2005) DOI: /j.gastro Copyright © 2005 American Gastroenterological Association Terms and Conditions

2 Figure 1 Examples of (A) neutral and (B) fearful facial expression used in the emotional context modulation experiments. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

3 Figure 2 Schematic outline of the gastric barostat protocol. Stepwise distentions always preceded the accommodation testing, and the same emotional context was never used twice on the same day: When anxiety was induced during the stepwise distentions, a neutral emotional state was induced after administration of the meal and vice versa. Barostat measurements continued for 60 minutes after the start of meal ingestion. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

4 Figure 3 (A) Pressure-volume relationship obtained by gradually increasing isobaric gastric distentions during neutral or anxious emotional context modulation. The slope of the pressure-volume curve was significantly lower (P < .01) during the anxious compared with the neutral emotional state, which was associated with significantly lower intraballoon volumes for distending pressures of 8 and 10 mm Hg greater than the MDP. *P < .05. (B) Corresponding mean perception scores for gradually increasing isobaric distentions during neutral or anxious emotional context modulation. The pressure-perception relationship was not significantly altered. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

5 Figure 4 (A) Mean intragastric volume at 5-minute intervals as measured with the barostat, before and after administration of a meal at time 0. Neutral or anxious emotional context modulation occurred during the first 10 minutes after meal ingestion. Gastric accommodation, quantified as the mean 1-hour increase in postprandial volume, was significantly lower after the anxiety compared with the neutral condition (P < .05). (B) Mean increase in intragastric volume during the first 10 minutes after ingestion of a meal. This time frame corresponds to the time of anxious or neutral emotional context manipulation. During the 10 minutes of emotion induction, the increase in intraballoon volume was significantly lower in the anxiety condition (analysis of variance; P < .005). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

6 Figure 5 Epigastric symptom rating scores at the end of a 10-minute nutrient challenge (30 mL/min, 1.5 kcal/mL) during neutral or anxious emotional context modulation. The anxious emotional state was associated with significantly higher scores for satiety, fullness, and bloating. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions


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