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One single dose of histidine–tryptophan–ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive.

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Presentation on theme: "One single dose of histidine–tryptophan–ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive."— Presentation transcript:

1 One single dose of histidine–tryptophan–ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: A prospective randomized study  Bjørn Braathen, MD, Anders Jeppsson, MD, PhD, Henrik Scherstén, MD, PhD, Ole M. Hagen, MD, Øystein Vengen, MD, PhD, Helena Rexius, MD, PhD, Vincenzo Lepore, MD, PhD, Theis Tønnessen, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 141, Issue 4, Pages (April 2011) DOI: /j.jtcvs Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 A, Maximum postoperative CK-MB with blood and HTK cardioplegia (P = .80). B, Maximum postoperative troponin-T with blood and HTK cardioplegia (P = .60). Values are mean ± standard error of the mean. CK-MB, Creatine kinase isoenzyme MB; HTK, histidine–tryptophan–ketoglutarate. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 A, Creatine kinase isoenzyme MB preoperatively and 7, 20, 44, and 68 hours postoperatively (P = .65 between groups). B, Troponin-T preoperatively and 7, 20, 44, and 68 hours postoperatively (P = .30 between groups). Values are mean ± standard error of the mean. CK-MB, Creatine kinase isoenzyme MB; HTK, histidine–tryptophan–ketoglutarate; Preop, preoperatively; PO, postoperatively. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 A and B, No correlation between cardiac enzymes and crossclamp time in the group of patients receiving cold blood cardioplegia. C and D, Positive correlation between cardiac enzymes and crossclamp time in the group of patients receiving HTK cardioplegia. Dashed lines show 95% confidence and prediction intervals. CK-MB, Creatine kinase isoenzyme MB; HTK, histidine–tryptophan–ketoglutarate. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions


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