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Bibi Petersen, Hans C. Wulf, Margarita Triguero-Mas, Peter A

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Presentation on theme: "Bibi Petersen, Hans C. Wulf, Margarita Triguero-Mas, Peter A"— Presentation transcript:

1 Sun and Ski Holidays Improve Vitamin D Status, but Are Associated with High Levels of DNA Damage 
Bibi Petersen, Hans C. Wulf, Margarita Triguero-Mas, Peter A. Philipsen, Elisabeth Thieden, Peter Olsen, Jakob Heydenreich, Payam Dadvand, Xavier Basagaña, Tove S. Liljendahl, Graham I. Harrison, Dan Segerbäck, Alois W. Schmalwieser, Antony R. Young, Mark J. Nieuwenhuijsen  Journal of Investigative Dermatology  Volume 134, Issue 11, Pages (November 2014) DOI: /jid Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Association between cumulative UVB exposure and cyclobutane thymine dimers (T–T dimers). A power model of the association between the T–T dimer post-level (nmol) and UVB exposure (kJm−2 × %) log2 (T–T dimer post-level)= × log2 (UVB exposure), P<0.0001, R2=0.68. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Association between cumulative UVB exposure and vitamin D. A logarithmic model of the association between UVB exposure (kJm−2 × %) and vitamin D post-level adjusting for vitamin D pre-level. Vitamin D measured as 25(OH)D (nmoll−1). (Vitamin D post-level= × vitamin D pre-level+3.57 × log2 (UVB exposure), P<0.0001, R2=0.75.) Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Association between cyclobutane thymine dimers (T–T dimers) and vitamin D. A linear model of the association between the T–T dimer post-level and vitamin D post-level adjusting for vitamin D pre-level. Vitamin D is measured as 25(OH)D (nmoll−1). (Vitamin D post-level= × vitamin D pre-level+2.75 ×, P<0.0001, R2=0.76.) Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions


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