1. Reversible Effects of Diuretics Added to Renin-Angiotensin-Aldosterone System Blockade: Impact on Interpretation of Long-term Kidney Function Outcome 
Maartje C.J. Slagman, MD, Gerjan Navis, MD, PhD, Gozewijn D. Laverman, MD, PhD 
American Journal of Kidney Diseases 
Volume 56, Issue 3, Pages (September 2010)
DOI: /j.ajkd
Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

2. Figure 1
Plot of creatinine clearance (CCr) over time. Curves a and b denote decreases in CCr that include or exclude the initial steeper decrease, respectively (mean slope, −7.6 ± 3.3 [SD] vs −3.5 ± 1.0 mL/min/y; P = 0.03). The diuretic-associated changes in CCr are paralleled by changes in proteinuria (lower plot), supporting the notion that the early decrease in CCr using diuretics reflects a hemodynamic effect, rather than progression of chronic kidney disease. Abbreviation: RAASi, renin-angiotensin-aldosterone system inhibition.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions