1. SP and KLF Transcription Factors in Digestive Physiology and Diseases
Chang-Kyung Kim, Ping He, Agnieszka B. Bialkowska, Vincent W. Yang 
Gastroenterology 
Volume 152, Issue 8, Pages (June 2017)
DOI: /j.gastro
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2. Figure 1
Structure of human SP and KLF proteins. The A, B, C, and D define the modules of SP1. AD, activation; RD, repression domain; TAD, transactivation (reviewed in Kaczynski et al,2 Bouwman and Philipsen,3 Lomberk and Urrutia,4 McConnell and Yang,5 and Lomberk et al6). The accession numbers of proteins used for this figure are listed per UniProtKB database as follows: SP1 (P08047), SP2 (Q02086), SP3 (Q02447), SP4 (Q02446), SP5 (Q6BEB4), SP6 (Q3SY56), SP7 (Q87DD2), SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (O43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD94), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82).
Adapted with permission from Bouwman and Philipsen.3
Gastroenterology  , DOI: ( /j.gastro )
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3. Figure 2
Post-translational modifications and co-factors that interact with SP and KLF proteins. SP/KLF protein is illustrated as a bar with the 3 zinc fingers identified near the carboxyl terminus. The various post-translational modifications are described above the protein and the various co-activators or co-repressors that interact with the protein below. HDAC, histone deacetylase; TF, transcription factor.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2017 AGA Institute Terms and Conditions

4. Figure 3
Expression patterns of SP and KLF proteins under physiologic conditions in the digestive system. The diagram illustrates the various organs or tissues in the digestive system, including the oral mucosa, esophagus, stomach, small intestine, colon, liver, and pancreas. Various members of SP and KLF proteins found in the given tissues or cell types are included in the figure. SMC, smooth muscle cell.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2017 AGA Institute Terms and Conditions