1. Mitochondrial membrane perturbations in cholestasis
Cecília M.P Rodrigues, Clifford J Steer 
Journal of Hepatology 
Volume 32, Issue 1, Pages (January 2000)
DOI: /S (00)

2. Fig. 1
Electron microscopy of isolated rat liver mitochondria incubated with either deoxycholic acid (DCA), UDCA, DCA plus UDCA, cyclosporine A (CsA), DCA plus CsA, or no addition (control). Deoxycholic acid induces morphologic changes associated with MPT in isolated mitochondria. UDCA and cyclosporine A inhibit deoxycholic acid-induced morphologic changes in isolated mitochondria after MPT (from reference 73). Magnification ⨯.
Journal of Hepatology  , DOI: ( /S (00) )

3. Fig. 2
Proposed model for bile acid-induced mitochondrial alterations during cholestasis. Hydrophobic bile acids such as deoxycholic acid can trigger mitochondria to release caspase-activating proteins. Cytochrome c and other proteins are released from the intermembrane space of mitochondria into the cytosol after organelle swelling and subsequent rupture of the outer membrane. In addition, efflux can also occur through channel opening without morphologic alterations. See text for more complete discussion.
Journal of Hepatology  , DOI: ( /S (00) )