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Reduced anticoagulation after mechanical aortic valve replacement: Interim results from the Prospective Randomized On-X Valve Anticoagulation Clinical.

Published byWouter van der Wal Modified over 5 years ago

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Presentation on theme: "Reduced anticoagulation after mechanical aortic valve replacement: Interim results from the Prospective Randomized On-X Valve Anticoagulation Clinical."— Presentation transcript:

1 Reduced anticoagulation after mechanical aortic valve replacement: Interim results from the Prospective Randomized On-X Valve Anticoagulation Clinical Trial randomized Food and Drug Administration investigational device exemption trial  John Puskas, MD, MSc, FACS, FACC, Marc Gerdisch, MD, Dennis Nichols, MD, Reed Quinn, MD, Charles Anderson, MD, Birger Rhenman, MD, Lilibeth Fermin, MD, Michael McGrath, MD, Bobby Kong, MD, Chad Hughes, MD, Gulshan Sethi, MD, Michael Wait, MD, Tomas Martin, MD, Allen Graeve, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 147, Issue 4, Pages e2 (April 2014) DOI: /j.jtcvs Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 International normalized ratio (INR) distributions.
The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Relationship between the international normalized ratio (INR) at the event and the event rates. TE, Thromboembolism. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Kaplan-Meier life tables with 5-year event-free rates. A, Kaplan-Meier plot of major or minor bleeding events. B, Kaplan-Meier plot of thromboembolism. SE, Standard error. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

5 Appendix E2 Consolidated Standards of Reporting Trials (CONSORT) 2010 flow diagram. Reprinted, with permission, from Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Ann Intern Med. 2010;152: The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

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