1. Torquetenovirus Dynamics and Immune Marker Properties in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Longitudinal Study 
Philipp Wohlfarth, Michael Leiner, Christian Schoergenhofer, Georg Hopfinger, Irene Goerzer, Elisabeth Puchhammer-Stoeckl, Werner Rabitsch 
Biology of Blood and Marrow Transplantation 
Volume 24, Issue 1, Pages (January 2018)
DOI: /j.bbmt
Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

2. Figure 1
TTV dynamics in subgroups of patients with viremia at baseline and with acute GVHD during follow-up. Only patients with positive TTV DNA at baseline (n = 40) were included for plotting and analysis of data in (A) to (D). Shown are TTV levels over time (A) in the overall subgroup of patients with a positive viral load at baseline, (B) according to disease category (lymphoid, n = 12; other, n = 28), (C) according to the intensity of the conditioning regimen (MAC, n = 20; RIC/NMA, n = 20), and (D) according to the use of ATG during conditioning (yes, n = 19; no, n = 21). Courses of TTV levels in patients with (grade II-IV, n = 18) and without (grade 0-I, n = 32) acute GVHD requiring systemic therapy are plotted in (E), with the time of onset of depicted horizontally (median, center line; IQR, gray bar; range, outer lines; for numbers, see text). TTV levels are plotted as median with IQR. The asterisk denotes statistical significance at P < .05 for comparison of TTV levels over time (A) or between groups (B-E). TTV levels in (A) were each compared with the last value that differed significantly from the previous measurement.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

3. Figure 2
Correlations of TTV increase with baseline values and between TTV levels and absolute lymphocyte counts and CMV and EBV levels. Figures show scatterplots of (A) maximum TTV level increase and baseline values and (B) lymphocyte counts, (C) CMV levels, (D) EBV levels, and TTV loads, respectively. The dashed red lines indicate lines of best fit for all respective measurements. The gray line in (A) indicates the line of best fit including only patients with positive TTV at baseline (rs = -.60; P < .01). Only measurements following engraftment are included in (B). The black line of best fit and dots in (C) analyze only patients receiving on ganciclovir or valganciclovir therapy (n = 14; rs = .40; P < .01), whereas the gray line and dots include only patients without antiviral therapy (n = 12; rs = -.22; P = .21).
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions