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An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease  Benjamin Ungar, Sandra Garcet, Juana Gonzalez, Nikhil.

Published byΝέφθυς Βουγιουκλάκης Modified over 5 years ago

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Presentation on theme: "An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease  Benjamin Ungar, Sandra Garcet, Juana Gonzalez, Nikhil."— Presentation transcript:

1 An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease 
Benjamin Ungar, Sandra Garcet, Juana Gonzalez, Nikhil Dhingra, Joel Correa da Rosa, Avner Shemer, James G. Krueger, Mayte Suarez-Farinas, Emma Guttman-Yassky  Journal of Investigative Dermatology  Volume 137, Issue 3, Pages (March 2017) DOI: /j.jid Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Atopic dermatitis (AD) serum cytokines and chemokines before and after cyclosporine A (CsA) treatment. Relative levels of AD serum markers (in log2 fold change [FCH]) (a) at baseline (vs. healthy control subjects) and (b) after CsA treatment. Mean ± standard error of the mean. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Serum versus skin levels of cytokines and chemokines. Scatterplot of the highest correlation between cytokines or chemokines in serum versus (a) levels of baseline lesional (LS) skin, (b) baseline nonlesional (NL) skin, and (c) NL skin after cyclosporine A (CsA) treatment. Regression lines in blue, with gray smoothed confidence interval. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

4 Figure 3 μScore models of baseline biomarker correlations with SCORAD. Representative top multivariate correlation models of SCORAD with baseline biomarkers in (a) lesional (LS) skin with (b) associated scatterplots, (c) nonlesional (NL) skin (d) with associated scatterplots, and (e) LS + NL + serum (f) with associated scatterplots. Regression lines in blue, with gray smoothed confidence interval. SCORAD, Scoring of AD; val, value. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

5 Figure 4 μScore models of therapeutic response biomarker correlations with SCORAD. Representative top multivariate correlation models of SCORAD with therapeutic response biomarkers in (a) lesional (LS) skin (b) with associated scatterplots, (c) nonlesional (NL) skin (d) with associated scatterplots, and (e) LS + NL + serum (f) with associated scatterplots. Regression lines in blue, with gray smoothed confidence intervals. SCORAD, Scoring of AD; val, value. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

6 Figure 5 μScore models of biomarker correlations with HistScore. Representative top multivariate correlation models of HistScore with biomarkers in (a) lesional (LS) + nonlesional (NL) + serum at baseline (b) with associated scatterplots, (c) therapeutic response biomarkers in LS skin (d) with associated scatterplots, and (e) therapeutic response biomarkers in LS + NL + serum (f) with associated scatterplots. Regression lines in blue, with gray smoothed confidence intervals. val, value. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2016 The Authors Terms and Conditions

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