1. Intramitochondrial Ca2+ Sensing by EMRE: The Matrix Outlook on Stimulus-Metabolism Coupling 
David N. Criddle, Alexei V. Tepikin 
Molecular Cell 
Volume 61, Issue 5, Pages (March 2016)
DOI: /j.molcel
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
The Effect of the Mitochondrial Matrix Ca2+ on the Ca2+ Entry into Mitochondria and Its Potential Downstream Responses
Shown is a simplified diagram illustrating Ca2+ entry into the mitochondrial matrix from the intermembrane space and its regulation. Ca2+ entry is mediated by the mitochondria calcium uniporter MCU and regulated by Ca2+ binding proteins MICU1 and MICU2. EMRE connects MCU with its regulators MICU1 and MICU2. Matrix Ca2+ regulates Ca2+ entry into mitochondria (measured as MCU current density IMiCa/Cm), and this regulation is mediated by EMRE (green arrow on the figure). The concentration dependence of the MCU current density from the matrix Ca2+ (green-colored trace in the center of the figure) is illustrated by the graph approximating the concentration dependence described in the paper by H. Vais and colleagues (Vais et al., 2016). Examples of downstream effects of mitochondrial matrix Ca2+ are shown in the lower part of the figure and include activation of mitochondrial permeability transition pore (MPTP) and acceleration of the Krebs cycle (KC).
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2016 Elsevier Inc. Terms and Conditions