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Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery  Vicente Orozco-Sevilla, MD,

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Presentation on theme: "Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery  Vicente Orozco-Sevilla, MD,"— Presentation transcript:

1 Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery  Vicente Orozco-Sevilla, MD, Rotem Naftalovich, BS, MBA, Thomas Hoffmann, BS, Dennis London, Eric Czernizer, Chenzi Yang, MD, Alan Dardik, MD, PhD, Herbert Dardik, MD  Journal of Vascular Surgery  Volume 58, Issue 5, Pages (November 2013) DOI: /j.jvs Copyright © 2013 Society for Vascular Surgery Terms and Conditions

2 Fig 1 A, Representative cross-sections of rat carotid arteries harvested at 2 weeks postinjury and stained with hematoxylin and eosin (H&E). Images show extent of intimal hyperplasia in the control (A) and suppression by phytochemical inhibitors: allicin (B), resveratrol (C), sulforaphane (SFN) (D), and epigallocatechin-3-gallate (EGCG) (E). Unflushed blood occupies the lumen of the specimens. Size bar represents 50 microns. n = 5-6 for each group. B, Representative cross-sections of rat carotid arteries harvested at 2 or 4 weeks after injury, stained with H&E. n = 6 for each group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Histogram depicting intimal area and intima:media ratios at 2 weeks after wire injury for control, allicin, resveratrol, sulforaphane (SFN), and epigallocatechin-3-gallate (EGCG) groups. A, Intimal area (measured in pixels) was significantly lower in the resveratrol, SFN, and EGCG groups than in the control group. B, Intima:media ratios were similar. Results are expressed as mean ± standard error of the mean; *P < .05 vs the control group; **P < .01 vs the control group. n = 5-6 for each group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Photomicrographs depicting representative images of immunohistochemistry, ×100 magnification. n = 6 for each group. EGCG, Epigallocatechin-3-gallate; ERK, extracellular signal-regulated kinase; JNK, c-jun N-terminal kinase. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Bar graph showing mean of control and epigallocatechin-3-gallate (EGCG)-treated arteries, examined by Western blot for phospho (p)-extracellular signal-regulated kinase (ERK)1: total (t) ERK1 ratio. Above each bar are representative images of the immunoreactive bands detected by Western blot. Control, n = 5; EGCG, n = 3. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

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