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Volume 146, Issue 5, Pages e1 (May 2014)

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Presentation on theme: "Volume 146, Issue 5, Pages e1 (May 2014)"— Presentation transcript:

1 Volume 146, Issue 5, Pages 1249-1255.e1 (May 2014)
A New Laboratory-Based Algorithm to Predict Development of Hepatocellular Carcinoma in Patients With Hepatitis C and Cirrhosis  Hashem B. El-Serag, Fasiha Kanwal, Jessica A. Davila, Jennifer Kramer, Peter Richardson  Gastroenterology  Volume 146, Issue 5, Pages e1 (May 2014) DOI: /j.gastro Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 The predicted HCC probability at different AFP levels is modified by ALT levels. Results of bivariate analysis. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

3 Figure 2 The positive and negative predictive values at different probability cutoffs resulting from a model containing AFP, age, ALT, platelets, and their interaction terms. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

4 Figure 3 Contour plot showing HCC probability at AFP level of 20 ng/mL as calculated from a predictive model containing AFP, age, ALT, and platelets. HCC probability at age 50 years (fixed) varies considerably over a range of ALT and platelets values. HCC probabilities are depicted in different colors. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

5 Figure 4 Contour plot showing HCC probability at AFP level of 20 ng/mL as calculated from a predictive model containing AFP, age, ALT, and platelets. HCC probability at age 70 years varies considerably over a range of ALT and platelets values. HCC probabilities are depicted in different colors. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

6 Supplementary Figure 1 (A) Predicted HCC probability modified by alkaline phosphatase. (B) Predicted HCC probability modified by bilirubin. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

7 Supplementary Figure 2 The positive and negative predictive values at different probability cutoffs resulting from a model containing AFP, age, ALT, platelets, and their interaction terms. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions


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