1. Volume 86, Issue 6, Pages 1074-1076 (December 2014)
Factors influencing clinical outcome in patients with primary hyperoxaluria type 1 
Sonia Fargue 
Kidney International 
Volume 86, Issue 6, Pages (December 2014)
DOI: /ki
Copyright © 2014 International Society of Nephrology Terms and Conditions

2. Figure 1
Factors potentially influencing the metabolism of oxalate and renal outcome in patients with primary hyperoxaluria type 1. AGT, alanine glyoxylate aminotransferase; B6, vitamin B6 (all vitamers); Ca, calcium; CaOx, calcium oxalate; G170R, p.Gly170Arg mutation; GO, glycolate oxidase; GR, glyoxylate reductase; HOGA, 4-hydroxy-2-oxoglutarate aldolase; mis, AGT missense mutation (other than G170R); null, AGT null mutation; PLP, pyridoxal-5′-phosphate; SLC26, SLC26 family of anion transporters. Plus and minus signs indicate favorable and unfavorable influence on primary hyperoxaluria (PH) evolution, respectively. Solid arrows indicate known influences in the metabolism of glyoxylate; dashed arrows, potential influences; and question marks, unknown factors. Endogenous factors have been shown to play the main role in the pathophysiology of PH1, PH2, and PH3.
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions