1. Bace2 mRNA expression in neurons, astrocytes, and oligodendrocytes.
Bace2 mRNA expression in neurons, astrocytes, and oligodendrocytes. Examples of Bace2 mRNA expression in neurons (A), astrocytes (B), and oligodendrocytes (C) as identified by co-localized cell type–specific markers Syp, Glast, and Mbp, respectively. Brain areas with highest neuronal (D), astrocyte (E), and oligodendrocyte (F) expression of Bace2. Neurons (G), as well as oligodendrocytes (H), expressing Bace2 also express Bace1. Purkinje cells express only Bace1 (I); similarly, dorsal hippocampus shows high Bace1 expression, but is virtually devoid of Bace2 (J). Few astrocytes throughout the brain focally express Bace1, whereas Bace2 is only expressed by astrocytes lining the lateral ventricle (K). Representative images from two adult (4 mo) and two young (P16–20) male WT mice. Syp, neuronal marker; Glast, astrocytic marker; and Mbp, oligodendrocyte marker.
Iryna Voytyuk et al. LSA 2018;1:e
© 2018 Voytyuk et al.