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Aneuploidies of chromosomes 1, 4, and 6 are not compatible with human embryos' implantation  M. Cristina Magli, M.Sc., Luca Gianaroli, M.D., Andor Crippa,

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Presentation on theme: "Aneuploidies of chromosomes 1, 4, and 6 are not compatible with human embryos' implantation  M. Cristina Magli, M.Sc., Luca Gianaroli, M.D., Andor Crippa,"— Presentation transcript:

1 Aneuploidies of chromosomes 1, 4, and 6 are not compatible with human embryos' implantation 
M. Cristina Magli, M.Sc., Luca Gianaroli, M.D., Andor Crippa, Ph.D., Santiago Munné, Ph.D., Francesca Robles, B.Sc., Anna P. Ferraretti, M.D.  Fertility and Sterility  Volume 94, Issue 6, Pages (November 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Chromosomal analysis of first polar body by multicolor FISH. (A) During the treatment cycle, the first polar body was tested for chromosomes 13 (red), 15 (orange), 16 (aqua), 18 (pink), 21 (green), and 22 (yellow). Three signals for chromosome 16 were present indicating that the oocyte was hypohaploid for chromosome 16. (B) The same polar body was rehybridized with the probes specific for the chromosomes 1 (orange), 4 (green), and 6 (aqua). The presence of three aqua signals indicated that the oocyte was hypohaploid also for chromosome 6. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Aneuploidy events in first polar body for single chromosomes. Chromosomes 6, 13, and 18 showed the lowest rate of variation. The P values are for comparisons between values with the same superscript letter. aefhkl P<0.001; bd P<0.005; cjo P<0.01; gimn P<0.025. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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