1. Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-β1 in ovariectomized rats 
S. Li, G. Niu, Y. Wu, G. Du, C. Huang, X. Yin, Z. Liu, C. Song, H. Leng 
Osteoarthritis and Cartilage 
Volume 24, Issue 2, Pages (February 2016)
DOI: /j.joca
Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
(A) Rat body weights and (B) uterus weights for all the groups. Values are the means ± 95% CI.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Changes in the serum 1α,25(OH)2D3 (A and B), 17β-estradiol (C and D), and serum C-telopeptide of type II collagen (CTX-II) (E and F) levels in all the groups (SHAM+CTL [●], OVX+CTL [■], SHAM+VDD [○], OVX+VDD [□], OVX+LOW [▲], OVX+MID [▽] and OVX+HIGH [△]). Values are the means ± 95% CI. P values are listed in Table I.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Sections from part of the knees of different groups. OVX+CTL, SHAM+VDD and OVX+VDD showed a similar mode of cartilage surface erosion. Arrows point to cartilage surface erosion. The images in the red frame are higher resolution images of the arrowed area. The histogram shows the quantification results of cartilage surface erosion for the whole joint in all groups. Bars represent 100 μm. Values are the means ± 95% CI.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Representative expression of transforming growth factor-β1 (TGF-β1), type II collagen (CII), matrix metalloproteinases (MMP)-9,-13 in the articular cartilage of the rats in the following groups: SHAM+CTL, OVX+CTL, SHAM+VDD, OVX+VDD and OVX+HIGH. Representative expression in the OVX+LOW and OVX+MID groups is not shown. IOD means integrated optical density. Bars represent 100 μm. Values are the means ± 95% CI.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
(A) The concentrations of TGF-β1 in chondrocytes treated with different concentrations of 1α,25(OH)2D3 (0,1–100 nM), stimulated with tumor necrosis factor TNF-α (+) or without TNF-α (−). After TNF-α stimulation, 1α,25(OH)2D3 increased the chondrocyte TGF-β1 expression in a dose-dependent manner. (B) The concentrations of CTX-II in chondrocytes treated with different concentrations of 1α,25(OH)2D3 (0,1–100 nM), stimulated with TNF-α (+) or without TNF-α (−). After TNF-α stimulation, 1α,25(OH)2D3 decreased the chondrocyte CTX-II release in a dose-dependent manner. (C) The CTX-II release from the ECM of chondrocytes treated with/without 10 nM 1α,25(OH)2D3, TNF-α and TGF-β receptor inhibitor (SB505124). The effects of 1α,25(OH)2D3 on TNF-α stimulated chondrocytes were contracted by TGF-β receptor inhibitor. Values are the means ± 95% CI.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions