1. Clinical experience with an implantable, intracardiac, continuous flow circulatory support device: physiologic implications and their relationship to patient selection 
O.H Frazier, MD, Timothy J Myers, BS, Stephen Westaby, MS, PhD, FETCS, Igor D Gregoric, MD 
The Annals of Thoracic Surgery 
Volume 77, Issue 1, Pages (January 2004)
DOI: /S (03)

2. Fig 1
The Jarvik 2000 ventricular assist system (Jarvik Heart Inc, New York, NY) consists of an implantable blood pump with an outflow graft, a power cable, an external controller, and a battery pack.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3. Fig 2
Arterial pressure tracing at standard pump speed settings. At 8000 and 9000 RPM the aortic valve is opening, whereas above 10,000 RPM the aortic valve remains closed. The pulse pressure decreases from 25 mm Hg at 8000 RPM to 6 mm Hg at 12,000 RPM. (BP = blood pressure; RPM = revolutions per minute.) (Reprinted from Frazier OH, et al, Circulation; 2002;105:2855–60 [8], with permission, ©Lippincott Williams & Wilkins.)
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4. Fig 3
Severe septal shift in a patient who developed acute respiratory distress syndrome and high pulmonary vascular resistance after Jarvik implant. Note the small dimensions of the left ventricular cavity. The patient died.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5. Fig 4
Scatterplot of the CO and the SVR in the bridge-to-transplant patients. Regression analysis reveals a strong correlation between the CO and SVR. Optimal CO is achieved at lower SVR values. Pump flow was 12,000 revolutions per minute. (CO = cardiac output; SVR = systemic vascular resistance.)
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6. Fig 5
Echocardiographic images of the aortic valve during Jarvik 2000 support. (A) The pump outflow is into the descending aorta, and the pump speed is set at 12,000 revolutions per minute (rpm). The cloudy appearance in the aortic root reflects stasis. (B) The same patient with a reduced rpm, which allowed the aortic valve to open and cleared the aortic root of stasis (pump speed, 9000 rpm). (C) In a different patient, with the outflow graft anastomosed to the ascending aorta, there is no stasis in the aortic root even when the aortic valve is closed (pump speed 14,000 rpm).
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

7. Fig 6
Measurement of coronary graft flow in 1 patient who underwent pump implantation and triple coronary artery bypass (ascending aortic graft placement). The right and left coronary flow increased substantially when the speed of the pump was increased from 8000 to 10,000 rpm, but did not increase above 10,000 rpm. • = right coronary flow; ■ = left coronary flow. (rpm = revolutions per minute.)
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

8. Fig 7
Pressure-volume loops calculated before implantation (left) and before explantation (right). The Emax reveals marked improvement in intrinsic myocardial function following 62 days of support with the continuous-flow pump.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )