1. Volume 72, Issue 2, Pages 145-150 (July 2007)
The endothelium-derived hyperpolarizing factor: insights from genetic animal models 
R. Köhler, J. Hoyer 
Kidney International 
Volume 72, Issue 2, Pages (July 2007)
DOI: /sj.ki
Copyright © 2007 International Society of Nephrology Terms and Conditions

2. Figure 1
Putative EDHF signalling pathways related to endothelial and smooth muscle ion-channel opening (upper panel). Impaired endothelial and smooth muscle hyperpolarization in IKCa/KCa3.1 KO mice leads to defective EDHF-mediated vasodilation and elevated systemic blood pressure (lower panel). AA, arachidonic acid; ACh, acetylcholine; BKCa, large-conductance Ca2+-activated K+ channel (KCa1.1); CYP, cytochrome P450 epoxygenase; EET, epoxyeicosatrienoic acid; ER, endoplasmic reticulum; GPCR, G-protein coupled receptor; IKCa, intermediate-conductance Ca2+-activated K+ channel (KCa3.1); Kir, inwardly-rectifying K+ channel; SKCa, small-conductance Ca2+-activated K+ channel (KCa2.3); VDCC, voltage-dependent Ca2+ channel.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions