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Glucose Restriction: Longevity SIRTainly, but without Building Muscle?

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Presentation on theme: "Glucose Restriction: Longevity SIRTainly, but without Building Muscle?"— Presentation transcript:

1 Glucose Restriction: Longevity SIRTainly, but without Building Muscle?
Carles Cantó, Johan Auwerx  Developmental Cell  Volume 14, Issue 5, Pages (May 2008) DOI: /j.devcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Possible Pleiotropic Actions of Glucose Restriction through AMPK and SIRT1 SIRT1 can deacetylate and inhibit MyoD, a key transcription factor for myogenesis. Activation of AMPK during glucose restriction triggers the activation of SIRT1, thereby blocking the induction of the myogenic program. However, triggering SIRT1 activity by AMPK could also translate into the regulation of other SIRT1 deacetylation targets, such as p53, peroxisome-proliferator activated receptor gamma coactivator 1α (PGC-1α), or the FOXO family of transcription factors, leading to a plethora of possible effects that perhaps extend beyond the regulation of myogenesis. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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