Presentation is loading. Please wait.

Presentation is loading. Please wait.

Quantification of Lipid Filtration and the Effects on Cerebral Injury During Cardiopulmonary Bypass  Richard W. Issitt, FCCP, Ian Harvey, LCCP, Bronagh.

Published byCarmelo Torres Modified over 5 years ago

Similar presentations

Presentation on theme: "Quantification of Lipid Filtration and the Effects on Cerebral Injury During Cardiopulmonary Bypass  Richard W. Issitt, FCCP, Ian Harvey, LCCP, Bronagh."— Presentation transcript:

1 Quantification of Lipid Filtration and the Effects on Cerebral Injury During Cardiopulmonary Bypass 
Richard W. Issitt, FCCP, Ian Harvey, LCCP, Bronagh Walsh, PhD, David Voegeli, PhD  The Annals of Thoracic Surgery  Volume 104, Issue 3, Pages (September 2017) DOI: /j.athoracsur Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Lipid microemboli under microscopy. Lipid microemboli observed as nonnucleated spherical cells (red circle) taken under light microscopy with 40/0.65 optics. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Before and after lipid microemboli (LME) counts. Data are presented as box and whiskers plots with boxes representing 25th to 75th centiles with median and whiskers as maximum and minimum values. Blue indicates the control group; red, the intervention group. Both groups showed significant changes in total LME counts compared with baseline and with each other (p < 0.001). The control group showed a mean increase of 115.7% in LME, and the filtration group saw an 82.8% decrease. (pre-op = preoperative.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Neuron-specific enolase (NSE) release. Data are presented as box and whiskers plots with boxes representing 25th to 75th centiles with median and whiskers as maximum and minimum values. Blue indicates the control group; red; the intervention group. Both groups saw a significant increase with peak concentrations at the end of cardiopulmonary bypass (p < 0.001); however, there was a significantly attenuated peak in the filtration group compared with the control group (p = 0.012). Repeated-measures analysis of variance showed significantly less NSE release in the filtration group throughout the sampling period (p = 0.002). (CPB = cardiopulmonary bypass; Post-op = postoperative; Pre-Op = preoperative.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 The RemoweLL lipid filtration system. The RemoweLL ECC system comprising two filtering mechanisms: a leucocyte filter and a lipid microemboli siphon. A 40-μm membrane provides multilayer filtration for leukocytes and lipids, whereas the siphon, at the base of the cardiotomy reservoir, prevents the reinfusion of the lipid-rich supernatant fluid that is then discarded. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Download ppt "Quantification of Lipid Filtration and the Effects on Cerebral Injury During Cardiopulmonary Bypass  Richard W. Issitt, FCCP, Ian Harvey, LCCP, Bronagh."

Similar presentations

The effect of cardiotomy suction on the brain injury marker S100β after cardiopulmonary bypass  Russell E Anderson, MD, PhD, Lars-Olof Hansson, MD, PhD,

The effect of cardiotomy suction on the brain injury marker S100β after cardiopulmonary bypass  Russell E Anderson, MD, PhD, Lars-Olof Hansson, MD, PhD,
Major Bleeding, Transfusions, and Anemia: The Deadly Triad of Cardiac Surgery  Marco Ranucci, MD, FESC, Ekaterina Baryshnikova, BD, Serenella Castelvecchio,

Major Bleeding, Transfusions, and Anemia: The Deadly Triad of Cardiac Surgery  Marco Ranucci, MD, FESC, Ekaterina Baryshnikova, BD, Serenella Castelvecchio,
Risk Index for Postoperative Acute Kidney Injury After Valvular Surgery Using Cardiopulmonary Bypass  Takashi Yamauchi, MD, PhD, Shigeru Miyagawa, MD,

Risk Index for Postoperative Acute Kidney Injury After Valvular Surgery Using Cardiopulmonary Bypass  Takashi Yamauchi, MD, PhD, Shigeru Miyagawa, MD,
The STS National Database

The STS National Database
Predictors of Acute Lung Injury and Severe Hypoxemia in Patients Undergoing Operative Talc Pleurodesis  Tomasz J. Kuzniar, MD, PhD, Matthew G. Blum, MD,

Predictors of Acute Lung Injury and Severe Hypoxemia in Patients Undergoing Operative Talc Pleurodesis  Tomasz J. Kuzniar, MD, PhD, Matthew G. Blum, MD,
Activation of neutrophils and monocytes by a leukocyte-depleting filter used throughout cardiopulmonary bypass  Minna Ilmakunnas, MD, Eero J. Pesonen,

Activation of neutrophils and monocytes by a leukocyte-depleting filter used throughout cardiopulmonary bypass  Minna Ilmakunnas, MD, Eero J. Pesonen,
Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C

Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C
B-Type Natriuretic Peptide as a Predictor of Postoperative Cardiopulmonary Complications in Elderly Patients Undergoing Pulmonary Resection for Lung Cancer 

B-Type Natriuretic Peptide as a Predictor of Postoperative Cardiopulmonary Complications in Elderly Patients Undergoing Pulmonary Resection for Lung Cancer 
Cardiac Surgery in Patients With Previous Hepatic or Renal Transplantation: A Pair- Matched Study  Mina Farag, MD, Marina Nikolic, MD, Rawa Arif, MD, Bastian.

Cardiac Surgery in Patients With Previous Hepatic or Renal Transplantation: A Pair- Matched Study  Mina Farag, MD, Marina Nikolic, MD, Rawa Arif, MD, Bastian.
Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein  Daijiro Hori, MD, Allen D. Everett, MD, Jennifer.

Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein  Daijiro Hori, MD, Allen D. Everett, MD, Jennifer.
The Annals of Thoracic Surgery

The Annals of Thoracic Surgery
Autologous Platelet-Rich Plasma Reduces Transfusions During Ascending Aortic Arch Repair: A Prospective, Randomized, Controlled Trial  Shao Feng Zhou,

Autologous Platelet-Rich Plasma Reduces Transfusions During Ascending Aortic Arch Repair: A Prospective, Randomized, Controlled Trial  Shao Feng Zhou,
Cerebrospinal Fluid Markers of Brain Injury, Inflammation, and Blood-Brain Barrier Dysfunction in Cardiac Surgery  Björn Reinsfelt, MD, PhD, Sven-Erik.

Cerebrospinal Fluid Markers of Brain Injury, Inflammation, and Blood-Brain Barrier Dysfunction in Cardiac Surgery  Björn Reinsfelt, MD, PhD, Sven-Erik.
Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up  Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,

Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up  Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,
Invited Commentary The Annals of Thoracic Surgery

Invited Commentary The Annals of Thoracic Surgery
Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery: Development of a Predictive Risk Algorithm  Mitchell J. Magee, MD, Morley A. Herbert,

Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery: Development of a Predictive Risk Algorithm  Mitchell J. Magee, MD, Morley A. Herbert,
Leukocyte depletion during cardiac operation: a new approach through the venous bypass circuit  Y.John Gu, MD, PhD, A.J de Vries, MD, Paulien Vos, Piet.

Leukocyte depletion during cardiac operation: a new approach through the venous bypass circuit  Y.John Gu, MD, PhD, A.J de Vries, MD, Paulien Vos, Piet.
Carbon Dioxide Field Flooding Reduces Neurologic Impairment After Open Heart Surgery  Sven Martens, MD, PhD, Katrin Neumann, MD, PhD, Christian Sodemann,

Carbon Dioxide Field Flooding Reduces Neurologic Impairment After Open Heart Surgery  Sven Martens, MD, PhD, Katrin Neumann, MD, PhD, Christian Sodemann,
Reply The Annals of Thoracic Surgery

Reply The Annals of Thoracic Surgery
Simple Index to Predict Likelihood of Skilled Nursing Facility Admission After Coronary Artery Bypass Grafting Among Older Patients  David C. Chang, PhD,

Simple Index to Predict Likelihood of Skilled Nursing Facility Admission After Coronary Artery Bypass Grafting Among Older Patients  David C. Chang, PhD,

Similar presentations

Ads by Google