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FIH1 (factor inhibiting HIF-1) in the kidney: more than an oxygen sensor?
Yasemin Sirin, Hermann Pavenstädt Kidney International Volume 78, Issue 9, Pages (November 2010) DOI: /ki Copyright © 2010 International Society of Nephrology Terms and Conditions
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Figure 1 Hypothetical model of the function of FIH1 in podocytes under atmospheric oxygen levels. Under atmospheric oxygen levels, HIF-1α is suppressed in podocytes. FIH1 may then hydroxylate signaling proteins, such as the Notch intracellular domain (NICD), which in turn induces a downregulation of the CXCR4 receptor, leading to the inhibition of podocyte inflammation. Kidney International , DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions
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