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The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of TH17 cell development  Silvia Rossi Paccani, PhD, Marisa Benagiano, PhD, Maria.

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Presentation on theme: "The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of TH17 cell development  Silvia Rossi Paccani, PhD, Marisa Benagiano, PhD, Maria."— Presentation transcript:

1 The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of TH17 cell development 
Silvia Rossi Paccani, PhD, Marisa Benagiano, PhD, Maria Teresa Savino, PhD, Francesca Finetti, PhD, Fiorella Tonello, PhD, Mario M. D’Elios, MD, Cosima T. Baldari, PhD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 6, Pages (June 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 ET promotes TH17 cell polarization through its cAMP-increasing activity. A, Quantification of IL-17, IL-21, IL-22, and relative mRNA levels of retinoic acid receptor–related orphan receptor γ (RORγ), IL-23 receptor, IL-1β receptor (A), IL-4 (B), or IFN-γ (C) in T cells (2-4 donors, duplicate samples) primed in the presence or absence of ET/EL1 or CyaA/CyaA-E5 and restimulated with anti-CD3 mAb for 24 hours. Error bars = SDs. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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