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Retinoic acid enhances lung growth after pneumonectomy

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Presentation on theme: "Retinoic acid enhances lung growth after pneumonectomy"— Presentation transcript:

1 Retinoic acid enhances lung growth after pneumonectomy
Aditya K Kaza, MD, Irving L Kron, MD, John A Kern, MD, Stewart M Long, MD, Steven M Fiser, MD, Richard P Nguyen, BS, Curtis G Tribble, MD, Victor E Laubach, PhD  The Annals of Thoracic Surgery  Volume 71, Issue 5, Pages (May 2001) DOI: /S (01)02478-X Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Initial and final total body weight (iTBW and fTBW) at 10- and 21-day intervals. ∗p = for iTBW versus fTBW. (P = pneumonectomy; R = pneumonectomy with administration of retinoic acid; S = sham thoracotomy.) The Annals of Thoracic Surgery  , DOI: ( /S (01)02478-X) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Lung volume index at 10- and 21-day < versus S10; ∗p < versus S10 and P10; &p < versus S21; #p < versus S21 and P21. (P = pneumonectomy; R = pneumonectomy with administration of retinoic acid; S = sham thoracotomy.) The Annals of Thoracic Surgery  , DOI: ( /S (01)02478-X) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Lung weight index at 10- and 21-day intervals. ∗p < versus S10 and < versus S21; #p < versus S21 and P21. (P = pneumonectomy; R = pneumonectomy with administration of retinoic acid; S = sham thoracotomy.) The Annals of Thoracic Surgery  , DOI: ( /S (01)02478-X) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Cellular proliferation index (% of dividing cells) at 21-day interval. #p < versus S21; ∗p < versus S21 and P21. (P = pneumonectomy; R = pneumonectomy with administration of retinoic acid; S = sham thoracotomy.) The Annals of Thoracic Surgery  , DOI: ( /S (01)02478-X) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Western blot analysis for the detection of epidermal growth factor receptor (EGFR) at 21 days. The Western blot is shown at top (EGFR, 170kDa). The computerized densitometry is shown below. ∗p = versus S21 and P21. (P = pneumonectomy; R = pneumonectomy with administration of retinoic acid; S = sham thoracotomy.) The Annals of Thoracic Surgery  , DOI: ( /S (01)02478-X) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions


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