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A Sequel to the Tale of p25/Cdk5 in Neurodegeneration

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Presentation on theme: "A Sequel to the Tale of p25/Cdk5 in Neurodegeneration"— Presentation transcript:

1 A Sequel to the Tale of p25/Cdk5 in Neurodegeneration
Burcin Ikiz, Serge Przedborski  Neuron  Volume 60, Issue 5, Pages (December 2008) DOI: /j.neuron Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Unifying Pathogenic Scenario for Aberrant p25/Cdk5-Mediated Neurodegeneration Abnormal production of p25 and activation of Cdk5 may be linked to Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), ischemia, and Alzheimer's disease (AD). The role of p25/Cdk5 in each of these different conditions has been related to unique signaling events as indicated. Collectively, these cellular perturbations culminate in the demise of the affected cells, likely by apoptosis. Neuron  , DOI: ( /j.neuron ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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