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Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways 

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Presentation on theme: "Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways "— Presentation transcript:

1 Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways  Christina Draijer, PhD, Carian E. Boorsma, MSc, Patricia Robbe, PhD, Wim Timens, MD, PhD, Machteld N. Hylkema, PhD, Nick H. Ten Hacken, MD, PhD, Maarten van den Berge, MD, PhD, Dirkje S. Postma, MD, PhD, Barbro N. Melgert, PhD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 1, Pages e3 (July 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Aligned dot plots with line shown at median of macrophages in bronchial biopsies of healthy subjects and males and females with asthma. Number of all CD68+ cells (A), IRF5+CD68+ (B), CD206+CD68+ (C), and IL-10+CD68+ cells (D). Linear regression of IRF5+CD68+ cells (E) and FEV1/FVC ratio, and IL-10+CD68+ cells (F) and FEV1/FVC ratio in patients with asthma. Number of IRF5+CD68+ cells and CD206+CD68+ cells in male and female patients with asthma with a lower FEV1 than 85%predicted (G and I) and with a higher FEV1 than 85%predicted (H and J). Number of all CD68+ cells (K), IRF5+CD68+ (L), CD206+CD68+ (M), and IL-10+CD68+ cells (N) in healthy subjects and patients with asthma using ICS and not using ICS. FVC, Forced vital capacity. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Representative photos of IRF5+CD68+ (A), CD206+CD68+ (B), and IL-10+CD68+ cells (C) (magnification 200×). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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