1. b. Bone marrow (CP) IM sensitive c. Bone marrow (CP) IM resistant
Supplemental Fig. 4
b Bone marrow (CP) IM sensitive
Bone marrow (CP) IM sensitive 20 40 60 80
100
120 C
IM-10
TG-5
TG-10
(mM)
Apoptosis (%) 10 20 30 40 50 60 70 C
IM-5
IM-10
TG-2.5
TG-5
Apoptosis (%)
(mM)
c Bone marrow (CP) IM resistant
100 80 60 40 20 C
IM-5
IM-10
TG-1.0
TG-2.0
TG-4.0
TG-5.0
Inhibitors (M)
Apoptosis (%)
CD34+ (Blast Crisis) a.
Bone marrow (CP), IM resistant 15 30 45 60 75 90 C
IM-10
TG-2.5
TG-5
TG-10
Apoptosis (%)
(mM)
d. Bone marrow (CP) IM resistant e.
CD34+(accel. phase) 20 40 60 80
100 C
IM-10
TG -10
WP-5.0
(mM)
Apoptosis(%) f.
Baf3-T315I cell line C
IM-5
IM-10
TG-1.0
TG-2.5
TG-5.0
TG-7.5
TG-10
Imatinib / TG (M)
120
100 80 60 40 20
Apoptosis (%)