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Clinical and Histologic Features of Azithromycin-Induced Liver Injury

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1 Clinical and Histologic Features of Azithromycin-Induced Liver Injury
Melissa A. Martinez, Raj Vuppalanchi, Robert J. Fontana, Andrew Stolz, David E. Kleiner, Paul H. Hayashi, Jiezhun Gu, Jay H. Hoofnagle, Naga Chalasani  Clinical Gastroenterology and Hepatology  Volume 13, Issue 2, Pages e3 (February 2015) DOI: /j.cgh Copyright © 2015 AGA Institute Terms and Conditions

2 Figure 1 Study flow describing the number of azithromycin cases and their salient characteristics among all patients enrolled into the DILIN Prospective Study. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2015 AGA Institute Terms and Conditions

3 Figure 2 Liver histology in patients with azithromycin hepatotoxicity. (A) Patient 3: an 11-year-old Caucasian girl with azithromycin hepatotoxicity underwent a liver biopsy at 20 days after DILI onset. A ductopenic portal area with mild inflammation is shown. (B) Zone 3 cholestasis with both hepatocellular and canalicular (arrows) bile accumulation. Panels A and B were taken from the same case, both H&E, 600×. (C) Patient 11: a 45-year-old Caucasian man with azithromycin hepatotoxicity underwent a liver biopsy at day 139 after DILI onset. Chronic hepatitis with perivenular inflammation and hemorrhage. H&E, 200×. P, portal area; V, vein. (D) Patient 10: mild veno-occlusive changes. There is a layer of fibroinflammatory tissue inside the vein (arrowheads). (Masson trichrome, 600×). Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2015 AGA Institute Terms and Conditions


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