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From Glioblastoma to Hepatitis C: It’s a Metabolism Thing
Milka Kostic Cell Chemical Biology Volume 23, Issue 11, Pages (November 2016) DOI: /j.chembiol Copyright © Terms and Conditions
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If you are a patient, this image is not something that you ever want to see—the evidence that you are suffering from glioblastoma (GBM), the most aggressive type of brain tumor, and one with a poor prognosis and withoutout a good treatment option. Villa et al. offer an interesting new option for GBM treatment by depriving GBM cells of cholesterol, a molecule they need to survive yet can’t make themselves. Source: Public domain via The Armed Forces Institute of Pathology (AFIP). Cell Chemical Biology , DOI: ( /j.chembiol ) Copyright © Terms and Conditions
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Hepatitis C virus (HCV) is a very persistent pathogen that most commonly leads to chronic liver infection, which greatly damages the organ, causing cirrhosis. In some cases, HCV infection can lead to hepatocellular carcinoma, as shown in this liver specimen. Levy et al. expose nuclear receptors as important host factors that work for and against the virus, opening new therapeutic opportunities. Photograph by Ed Uthman, MD. Public domain. Cell Chemical Biology , DOI: ( /j.chembiol ) Copyright © Terms and Conditions
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