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Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high.

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Presentation on theme: "Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high."— Presentation transcript:

1 Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high cholesterol diet  P.B. Chan, C. Wen, C. Yan, K. Chiu  Osteoarthritis and Cartilage  Volume 23, Pages A311-A312 (April 2015) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1. Trabecular thickness of TET mice under high fat & high cholesterol diet is significantly higher than the other three groups. Osteoarthritis and Cartilage  , A311-A312DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2. Bone surface to volume ratio of TET mice under high fat & high cholesterol diet is lower than the other three groups, indicating less bone resorption. Osteoarthritis and Cartilage  , A311-A312DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Figure 3. There bone volume fraction of subchondral bone in TET-mice is drastically increased upon high fat & high cholesterol diet. Osteoarthritis and Cartilage  , A311-A312DOI: ( /j.joca ) Copyright © Terms and Conditions

5 Figure 4. TET mice fed with high fat & high cholesterol diet had more proteoglycan loss when compared. Osteoarthritis and Cartilage  , A311-A312DOI: ( /j.joca ) Copyright © Terms and Conditions

6 Figure 5. TET mice fed with high fat & high cholesterol diet had more osteoclastic bone resoprtion activity. Osteoarthritis and Cartilage  , A311-A312DOI: ( /j.joca ) Copyright © Terms and Conditions

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