1. Relationship between prechallenge AVA-induced TNA levels and probability of animal survival following lethal challenge with B. anthracis spores in rabbit (A) and NHP (B) preexposure prophylaxis studies.
Relationship between prechallenge AVA-induced TNA levels and probability of animal survival following lethal challenge with B. anthracis spores in rabbit (A) and NHP (B) preexposure prophylaxis studies. Logistic regression models were fitted to the survival curve and either day 69 TNA NF50 levels in rabbits (A) (n = 96) or day 70 TNA NF50 levels in NHPs (B) (n = 39) in order to assess antibody level immediately prior to anthrax challenge as a predictor of survival in the vaccinated animals. Individual values below the LOQ were replaced with the LOQ value (0.086 for rabbit samples and for NHP samples). The graphs represent the logistic curves fitted to the data (solid lines) and 95% confidence intervals (dashed lines). Individual animal data points are represented by open-circle symbols (○); survival = 1; death = 0.
Boris Ionin et al. Clin. Vaccine Immunol. 2013; doi: /CVI