1. The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity
Noelia Escobedo, Guillermo Oliver 
Cell Metabolism 
Volume 26, Issue 4, Pages (October 2017)
DOI: /j.cmet
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Lymphatic Vascular Defects Contribute to Adult-Onset Obesity
In Prox1+/− mice, compromised lymphatic vascular integrity causes subtle leakage of lymph. FFA-containing lymph accumulates in the nearby tissues, particularly in the visceral area, where it induces de novo differentiation of fat cell precursors, fat cell hypertrophy, and eventually adipocyte proliferation. With age, Prox1+/− mice became progressively obese.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2017 Elsevier Inc. Terms and Conditions

3. Figure 2 Presence of Lymphatic Vessels in Fat Depots of Adult Mice
Visceral fat depots were dissected and subject to whole-mount immunostaining with antibodies against lymphatic endothelial cells (Lyve1 and Prox1) and adipocytes (Perilipin). Lymphatic vessels are seen deep inside the WAT and nearby blood vessels (data not shown). LV, lymphatic vessel. Scale bar, 30 μM.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2017 Elsevier Inc. Terms and Conditions