1. Myc increases the instability of lac operator repeats.
Myc increases the instability of lac operator repeats. (A) Quantification of the percentage of micronuclei containing lacR signals in 3T3lacO cells that had been infected with Myc overexpressing retroviruses for 72 h. (B) Quantification of the percentage of anaphases showing a lacR signal at an anaphase bridge in 3T3lacO cells that had been infected with Myc overexpressing retroviruses for 72 h. Control cells were infected with retroviruses derived from the empty vector. (C) Example from Myc‐infected 3T3lacO cells that illustrates the presence of multiple lacR signals in these cells. LacR was transfected 24 h before the analysis. Error bars indicate s.d. from three independent experiments. *P<0.05; Student's t‐test. DAPI, 4,6‐diamidino‐2‐phenylindole; lacO, lac operator; lacR, lac repressor.
Ariana Jacome, and Oscar Fernandez‐Capetillo EMBO Rep. 2011;12:
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