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The quest for autoreactive antibodies in nasal polyps

Published byMeghan Anthony Modified over 5 years ago

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Presentation on theme: "The quest for autoreactive antibodies in nasal polyps"— Presentation transcript:

1 The quest for autoreactive antibodies in nasal polyps
Els De Schryver, MD, Lien Calus, MD, PhD, Henryk Bonte, MD, De Ruyck Natalie, MD, Hannah Gould, PhD, Erin Donovan, PhD, Dirk Elewaut, MD, PhD, Rudolf Valenta, MD, Irene Mittermann, PhD, Jan Gutermuth, MD, Tanja Seher, PhD, MD, Robert P. Schleimer, PhD, Bruce K. Tan, MD, MS, Lara Derycke, PhD, Thibaut Van Zele, MD, PhD, Claus Bachert, MD, PhD, Philippe Gevaert, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 3, Pages e5 (September 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 The detection of local and serum anti-dsDNA IgG. Data are expressed in Box-Whisker plots presenting the results of local and systemic anti-dsDNA IgG in patients with nasal polyps and healthy subjects. Significance (P) values after Mann-Whitney U test are represented by * when P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 The detection of autoreactive IgE to the human epithelial cell line A431 (A), of local anti-IgE IgG (B) and of autoreactive IgE to skin and lung epithelium (C). A, Positive (atopic dermatitis [AD]) and negative controls are shown in this western blot. Molecular weights (kDa) are indicated at the left and right margins. B, Each subject's anti-IgE IgG value is presented in the bar graph. The 75th percentile (8.991 ng/mL) is represented by the dotted line. C, Median values, 25th and 75th percentiles are presented by Box-Whisker plots. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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