2. Circulation 2001;104:

3. Median Time (hrs) Between Symptom Onset and Treatment
Time from Symptom Onset to Study Treatment in Large Scale Thrombolytic Trials
2.8
2.7
2.9
2.8
2.7
2.7
Median Time (hrs) Between Symptom Onset and Treatment
GUSTO I
90-93
GUSTO III
95-97
InTIME II
97-99
ASSENT II
97-98
GUSTO V
99-01
ASSENT 3
00-01
Gibson CM, Circulation 2001;104:

4. Benefits of PCI vs Lysis: The Importance of Timing
Kent DM et al Eff Clin Pract 4: 214, 2001

5. Primary PCI for STEMI Time to Reperfusion and 30 Day Mortality
CADILLAC
Zwolle
N= 2002 N=
9.6
P=0.04 (< 3h v > 3 h)
P < 0.001
% Mortality
5.6
2.3
2.2
3.1
2.5
0.9
Cox ACC ‘03 Abst 827-1
DeLuca ACC ‘03 Abst 827-3
Time to Reperfusion (h)

6. NRMI-2: Primary PCI Door-to-Balloon time vs. Mortality
Lecture Notes
Shown here are the raw absolute mortality rates for a variety of door to balloon times.
References
1. Cannon CP et al, JAMA 2000
Door-to-Balloon Time (minutes)

7. Door to Balloon Times Among Patients Transferred in NRMI 4
Data:
50th: 8 Min.
25th: 4 Min.
75th: 16 Min.
Data to
Cath Lab Arrival:
50th: 137 Min.
25th: 87 Min.
75th: 220 Min.
Cath Lab to
Balloon:
50th: 39 Min.
25th: 29 Min
75th: 53 Min. 8
137 39
Lecture Notes
Shown here is current data from the NRMI. Currently in the US, the median door to balloon time is 198 minutes. This is much longer than the 114 minutes in DANAMI 2.
References
NRMI 4 data on file.
Total Door to Balloon Time: minutes (25th: 137; 75th: 281)
Percent of Patients with Door to Balloon Time < 90 Min.: 4.8%
Sample Size: 1,292; Time Period: October 2000 – September 2001
Gibson 2003
NRMI 4 Transfer-In Annual Data Report 2002

8. DANAMI vs US AMI: Are We As Quick In The US?
198 Min.
110 Min.
Median Time (Min.)
90 Min.
DANAMI
On Site 1o PCI
DANAMI
Transfer 1o PCI
US AMI
Transfer 1o PCI