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Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues  Assunta De Rienzo, Robert W. Cook, Jeff Wilkinson,

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Presentation on theme: "Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues  Assunta De Rienzo, Robert W. Cook, Jeff Wilkinson,"— Presentation transcript:

1 Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues  Assunta De Rienzo, Robert W. Cook, Jeff Wilkinson, Corinne E. Gustafson, Waqas Amin, Clare E. Johnson, Kristen M. Oelschlager, Derek J. Maetzold, John F. Stone, Michael D. Feldman, Michael J. Becich, Beow Y. Yeap, William G. Richards, Raphael Bueno  The Journal of Molecular Diagnostics  Volume 19, Issue 1, Pages (January 2017) DOI: /j.jmoldx Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 Schematic representation of the research and clinical laboratory methods used for performing the test, using protocols for high-throughput formalin-fixed, paraffin-embedded (FFPE) and standard frozen samples. The clinical laboratory method was performed according to standard operating procedures developed to allow for the use of FFPE surgical biopsy tissue samples of malignant pleural mesothelioma. qPCR, real-time quantitative PCR. The Journal of Molecular Diagnostics  , 65-71DOI: ( /j.jmoldx ) Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 Overall survival in the validation cohort. Survival outcomes in the cases were predicted by gene expression score alone (A), or in combination with the clinical factors of histologic examination (epithelial versus nonepithelial) and lymph node involvement (absent or present) (B). The Journal of Molecular Diagnostics  , 65-71DOI: ( /j.jmoldx ) Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

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