1. Bisphosphonates: Mechanism of Action and Role in Clinical Practice
Matthew T. Drake, MD, PhD, Bart L. Clarke, MD, Sundeep Khosla, MD 
Mayo Clinic Proceedings 
Volume 83, Issue 9, Pages (September 2008)
DOI: /
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2. FIGURE 1
Bisphosphonate structures and approximate relative potencies6 for osteoclast inhibition.
Mayo Clinic Proceedings  , DOI: ( / )
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3. FIGURE 2
A, Nitrogen-containing bisphosphonates selectively inhibit farnesyl pyrophosphate synthase (FPPS) within osteoclasts. B, Osteoclast endocytosis of bisphosphonate from the bone surface leads to FPPS inhibition and osteoclast apoptosis. BP = nitrogen-containing bisphosphonate; HMG-CoA = 3-hydroxy-3-methylglutaryl coenzyme A.
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions