Download presentation
Presentation is loading. Please wait.
Published byAttila Gál Modified over 5 years ago
1
A Variant in MCF2L Is Associated with Osteoarthritis
Aaron G. Day-Williams, Lorraine Southam, Kalliope Panoutsopoulou, Nigel W. Rayner, Tonu Esko, Karol Estrada, Hafdis T. Helgadottir, Albert Hofman, Throvaldur Ingvarsson, Helgi Jonsson, Aime Keis, Hanneke J.M. Kerkhof, Gudmar Thorleifsson, Nigel K. Arden, Andrew Carr, Kay Chapman, Panos Deloukas, John Loughlin, Andrew McCaskie, William E.R. Ollier, Stuart H. Ralston, Timothy D. Spector, Gillian A. Wallis, J. Mark Wilkinson, Nadim Aslam, Fraser Birell, Ian Carluke, John Joseph, Ashok Rai, Mike Reed, Kirsten Walker, Sally A. Doherty, Ingileif Jonsdottir, Rose A. Maciewicz, Kenneth R. Muir, Andres Metspalu, Fernando Rivadeneira, Kari Stefansson, Unnur Styrkarsdottir, Andre G. Uitterlinden, Joyce B.J. van Meurs, Weiya Zhang, Ana M. Valdes, Michael Doherty, Eleftheria Zeggini The American Journal of Human Genetics Volume 89, Issue 3, Pages (September 2011) DOI: /j.ajhg Copyright © 2011 The American Society of Human Genetics Terms and Conditions
2
Figure 1 Overview of Study Design
The American Journal of Human Genetics , DOI: ( /j.ajhg ) Copyright © 2011 The American Society of Human Genetics Terms and Conditions
3
Figure 2 Forest Plot of OA Association and Meta-Analysis Results for rs The purple squares designate the estimated Odds Ratio (OR) for each individual study and the error bars extending out on both sides show the 95% confidence interval for the OR estimate. The pink diamond designates the estimated OR of the fixed effects meta-analysis of all the studies. The American Journal of Human Genetics , DOI: ( /j.ajhg ) Copyright © 2011 The American Society of Human Genetics Terms and Conditions
4
Figure 3 Comparison of Regional Association Plots at the Chromosome 13 Association Signal Evidence for association in the rs region for (A) arcOGEN GWAS directly typed analysis,8 (B) arcOGEN HapMap3 imputation analysis, and (C) arcOGEN 1KGP final pilot 1 release imputation analysis. The x axis shows the build 36 chromosome 13 base position ± 500 kb of rs The left y axis is the −log (p value) of SNPs in the region, and the right y axis is the recombination rate (cM/Mb) as calculated from the pilot 1 release of the 1KGP. Each diamond represents a variant and is colored according to its correlation (r2) with rs The green arrows below provide an overview of the genes in the region and their transcriptional direction. Imputed variants are denoted by circles and directly typed variants are denoted by diamonds. The American Journal of Human Genetics , DOI: ( /j.ajhg ) Copyright © 2011 The American Society of Human Genetics Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.