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Ventricular constraint in severe heart failure halts decline in cardiovascular function associated with experimental dilated cardiomyopathy  Jai S Raman,

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Presentation on theme: "Ventricular constraint in severe heart failure halts decline in cardiovascular function associated with experimental dilated cardiomyopathy  Jai S Raman,"— Presentation transcript:

1 Ventricular constraint in severe heart failure halts decline in cardiovascular function associated with experimental dilated cardiomyopathy  Jai S Raman, MMed, FRACS, Melissa J Byrne, BSc, BAppSc (Hons), John M Power, BVSc, PhD, Clif A Alferness, BSEE  The Annals of Thoracic Surgery  Volume 76, Issue 1, Pages (July 2003) DOI: /S (03)

2 Fig 1 Depiction of an Acorn CSD implant.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3 Fig 2 Mean values for left ventricular ejection fraction throughout the protocol. Hatched bars = cardiac support device (CSD); open bars = nil implant protocol; arrow = CSD implantation. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4 Fig 3 Submaximal exercise protocol: mean positive ratio of change of ventricular pressure to change in time ([+dP/dtmax] mm Hg/s). Solid boxes = baseline cardiac support device (CSD) implant; open boxes = baseline nil procedure; solid circles = advanced heart failure, CSD implant; open circles = advanced heart failure, nil procedure; dashed vertical line = stop treadmill. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5 Fig 4 Mean values for left ventricular long axis area (cm2) at each stage of the protocol. Hatched bars = cardiac support device (CSD) implant protocol; open bars = nil implant protocol; arrow = CSD implantation. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6 Fig 5 Mean mitral regurgitation (scored 0 to 3) throughout the protocol. Hatched bars = cardiac support device (CSD) implant protocol; open bars = nil implant protocol; arrow = CSD implantation. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

7 Fig 6 Mean resting left ventricular end diastolic pressure (mm Hg). Hatched bars = cardiac support device (CSD) implant protocol; open bars = nil implant protocol; arrow = CSD implantation. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

8 Fig 7 Mean cardiac output values (L/min). Hatched bars = cardiac support device (CSD) implant protocol; open bars = nil implant protocol; arrow = CSD implantation. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

9 Fig 8 Submaximal exercise protocol: mean −dP/dtmax (mm Hg/s). Solid boxes = baseline cardiac support device (CSD) implant; open boxes = baseline nil procedure; solid circles = advanced heart failure, CSD implant; open circles = advanced heart failure, nil procedure; dashed vertical line = stop treadmill. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

10 Fig 9 Mean resting left ventricular wall stress (dynes/cm2). Hatched bars = cardiac support device (CSD) implant protocol; open bars = nil implant protocol; arrow = CSD implantation. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

11 Fig 10 Histologic hematoxylin and eosin stained sections taken from the left ventricular freewall in sheep with cardiac support device (CSD) implants of (A) 1 month, (B) 6 month, and (C) 12 month duration. The F denotes the cut edges of the yarn from the Acorn Corcap CSD. The Annals of Thoracic Surgery  , DOI: ( /S (03) )


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