1. Focal Targeted Therapy Will Be a Future Treatment Modality for Early Stage Prostate Cancer 
Jean J.M.C.H. de la Rosette, Vladimir Mouraviev, Thomas J. Polascik 
European Urology Supplements 
Volume 8, Issue 5, Pages (April 2009)
DOI: /j.eursup
Copyright © 2009 European Association of Urology Terms and Conditions

2. Fig. 1
Transrectal ultrasonography (TRUS) and macroscopic pathology of prostate cancer lesions; (A) gray-scale (B-mode) imaging; (B) contrast-enhanced TRUS; (C) gross pathology. Adapted from Wink et al [38].
European Urology Supplements 2009 8, DOI: ( /j.eursup )
Copyright © 2009 European Association of Urology Terms and Conditions

3. Fig. 2
Transrectal ultrasonography: (A) gray-scale B-mode; (B) three-dimensional transrectal acoustic radiation force impulse imaging of cancer lesions; (C) matching pathology. Adapted from Zhai et al [39].
ARFI=acoustic radiation force impulse.
European Urology Supplements 2009 8, DOI: ( /j.eursup )
Copyright © 2009 European Association of Urology Terms and Conditions

4. Fig. 3
Conceptual schematic of treatment options for focal therapy: (A) true focal ablation; (B) hemiablation: the ablation zone is extended to include the ipsilateral neurovascular bundle and margin (treatment of possible extracapsular extension of disease); (C) 75% ablation: note that 25% of the gland (untreated area) will be on an active surveillance protocol; (D) near-total ablation: some undetermined amount of parenchyma will not be treated to maintain the neurovascular bundle on that side. Adapted from Polascik [53].
NVB=neurovascular bundle.
European Urology Supplements 2009 8, DOI: ( /j.eursup )
Copyright © 2009 European Association of Urology Terms and Conditions