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Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis  Juan Gui, Rui-hao Wang  Reproductive.

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Presentation on theme: "Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis  Juan Gui, Rui-hao Wang  Reproductive."— Presentation transcript:

1 Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis  Juan Gui, Rui-hao Wang  Reproductive BioMedicine Online  Volume 35, Issue 1, Pages (July 2017) DOI: /j.rbmo Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 Flow chart of literature search and study inclusion.
Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Funnel plot assessment of publication bias.
Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions

4 Figure 3 Forest plot graphs for the comparison of heart rate (Panel A) and systolic blood pressure (Panel B) between women with polycystic ovarian syndrome and women in the control group. A random-effects model was used in this meta-analysis, and standardized mean differences (SMDs) were used to measure the effect size. A positive effect indicates lower values in women with PCOS than women, and vice versa. There were tendencies toward higher HR and SBP in women with PCOS than women in the control group. The study by Hashim et al. (2015) had two cohorts of women with PCOS, Hashim et al. (2015) (a) only included obese women with PCOS, while Hashim et al. (2015) (b) only included non-obese women with PCOS. CI = confidence interval; HR = heart rate; PCOS = polycystic ovarian syndrome; SBP = systolic blood pressure; SD = standard deviation. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions

5 Figure 4 Forest plot graphs for the comparison of SDNN (Panel A) and pNN50 (Panel B) between women with polycystic ovarian syndrome and women in the control group. A random-effects model was used in this meta-analysis, and standardized mean differences (SMDs) were used to measure the effect size. A negative effect is indicated by lower values. SDNN and pNN50 were significantly lower in women with PCOS compared with women in the control group (P = 0.03 and P = 0.04, respectively). The study by Hashim et al. (2015) had two cohorts of women with PCOS, Hashim et al. (2015) (a) only included obese women with PCOS, while Hashim et al. (2015) (b) only included non-obese women with PCOS. pNN50 = percentage of the number of interval differences of successive normal-to-normal RR intervals greater than 50 ms among the total number of RR intervals; SDNN = standard deviation of normal-to-normal RR intervals. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions


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