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mTOR: The Master Regulator

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Presentation on theme: "mTOR: The Master Regulator"— Presentation transcript:

1 mTOR: The Master Regulator
Cell  Volume 149, Issue 5, (May 2012) DOI: /j.cell Copyright © Terms and Conditions

2 Immunofluorescence of wild-type (left) and PTENL/L prostate stained for the proinvasion YB-1 protein, translationally regulated by eIF4E. (Insets) Magnification of individual epithelial cells. Image courtesy of A. Hsieh. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

3 Chronic mTORC1 activation in mice with liver-specific knockout of Tsc1 (LTsc1KO) causes a defect in autophagy, as indicated by increased p62 staining and aggregation (arrow), which contributes to liver damage and inflammatory cell infiltration (I). Image courtesy of B. Manning. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

4 Arrowheads point to colocalization of SH3BP4 (green) with RagBGDP (red) in HeLa cells. Image courtesy of Y.M. Kim and D.H. Kim. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

5 Rapamycin was discovered in soil samples taken from Easter Island, or Rapa Nui in Polynesian; the drug was named accordingly. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions


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