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Addiction: Pulling at the Neural Threads of Social Behaviors

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Presentation on theme: "Addiction: Pulling at the Neural Threads of Social Behaviors"— Presentation transcript:

1 Addiction: Pulling at the Neural Threads of Social Behaviors
Nora D. Volkow, Ruben D. Baler, Rita Z. Goldstein  Neuron  Volume 69, Issue 4, Pages (February 2011) DOI: /j.neuron Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Model Proposing a Network of Four Circuits Involved with Addiction: Reward, Motivation/Drive, Memory, and Control These circuits work together and change with experience. Each is linked to an important concept: reward (value of positive and negative reinforcers), drive (incentive motivation), memory (learned associations/conditioning), and control (conflict resolution). During addiction, the enhanced value of the drug in the reward, motivation, and memory circuits overcomes the inhibitory control exerted by the prefrontal cortex, thereby favoring a positive-feedback loop initiated by the consumption of the drug and perpetuated by the enhanced activation of the motivation/drive and memory circuits (reprinted with permission [Volkow et al., 2003]). Neuron  , DOI: ( /j.neuron ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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