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Volume 17, Issue 8, Pages (August 2016)

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Presentation on theme: "Volume 17, Issue 8, Pages (August 2016)"— Presentation transcript:

1 Volume 17, Issue 8, Pages 1094-1104 (August 2016)
Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial  Amelia O Clive, PhD, Hazel Taylor, MSc, Lee Dobson, MBChB, Paula Wilson, FRCR, Emma de Winton, FRCR, Niki Panakis, FRCR, Justin Pepperell, MD, Timothy Howell, DM, Samuel A Stewart, PhD, Erika Penz, FRCPC, Nikki Jordan, MSc, Anna J Morley, BSc, Natalie Zahan-Evans, BSc, Sarah Smith, BSc, Timothy J P Batchelor, FRCS, Adrian Marchbank, FRCS, Lesley Bishop, MD, Alina A Ionescu, MD, Mike Bayne, MD, Samantha Cooper, FRCP, Anthony Kerry, FRCP, Peter Jenkins, PhD, Elizabeth Toy, FRCR, Vallipuram Vigneswaran, MD, James Gildersleve, FRCR, Merina Ahmed, MD[Res], Fiona McDonald, MD[Res], Mick Button, MA, Conrad Lewanski, FRCR, Charles Comins, FRCR, Muthukumar Dakshinamoorthy, FRCR, Prof Y C Gary Lee, PhD, Najib M Rahman, DPhil, Prof Nick A Maskell, DM  The Lancet Oncology  Volume 17, Issue 8, Pages (August 2016) DOI: /S (16)30095-X Copyright © 2016 Clive et al. Open Access article distributed under the terms of CC BY Terms and Conditions

2 Figure 1 Trial profile *One patient randomised after CT-guided biopsy and more than 35 days after the pleural intervention; three patients randomised more than 35 days after the pleural intervention. The Lancet Oncology  , DOI: ( /S (16)30095-X) Copyright © 2016 Clive et al. Open Access article distributed under the terms of CC BY Terms and Conditions

3 Figure 2 Time to development of PTM, by treatment group and histological subtype PTM=procedure-tract metastasis. The Lancet Oncology  , DOI: ( /S (16)30095-X) Copyright © 2016 Clive et al. Open Access article distributed under the terms of CC BY Terms and Conditions

4 Figure 3 Overall survival from randomisation HR=hazard ratio.
The Lancet Oncology  , DOI: ( /S (16)30095-X) Copyright © 2016 Clive et al. Open Access article distributed under the terms of CC BY Terms and Conditions


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