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An artificial nanoemulsion carrying paclitaxel decreases the transplant heart vascular disease: A study in a rabbit graft model  Domingos D. Lourenço-Filho,

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Presentation on theme: "An artificial nanoemulsion carrying paclitaxel decreases the transplant heart vascular disease: A study in a rabbit graft model  Domingos D. Lourenço-Filho,"— Presentation transcript:

1 An artificial nanoemulsion carrying paclitaxel decreases the transplant heart vascular disease: A study in a rabbit graft model  Domingos D. Lourenço-Filho, MD, PhD, Raul C. Maranhão, MD, PhD, Carlos A. Méndez-Contreras, MD, Elaine R. Tavares, BSci, Fatima R. Freitas, PhD, Noedir A. Stolf, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 141, Issue 6, Pages (June 2011) DOI: /j.jtcvs Copyright © Terms and Conditions

2 Figure 1 Uptake by different tissues of cholesterol-rich nanoemulsions labeled with [14C]-cholesteryl oleate ether 24 hours after intravenous injection into rabbits. ∗P = 313 versus native heart. Data are expressed as percentage uptake and normalized by gram as means ± standard errors of the mean. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

3 Figure 2 Immunohistochemistry of myocardial and arterial tissues from native and grafted hearts. Photomicrographs of 3,3′-Diaminobenzidine chromogen immunostaining for macrophages (A; RAM-11), (B) CD35, (C) α-actin, and (D) elastic lamina stained with Verhoeff–van Gieson stain. (Original magnifications: 100× [A, C, and D] and 200× [B].) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © Terms and Conditions


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