1. Supplemental Digital Content 11
Supplemental Digital Content 11. (A) Motor nerve terminals from intrinsic foot muscle showing dense accumulation of tubulovesicular membranous profiles and degenerating mitochondria at 40 weeks of age. Bar = 500 nm. Inset shows the enlargement of tubulovesicular organelles from the same end-plate. Bar = 100 nm. (B) A partially denervated neuromuscular junction at 4 weeks of age showing Schwann cell processes (arrows) in the primary synaptic cleft. Arrowhead points a part of nerve terminal showing tubulovesicular organelle accumulation. Bar = 500 nm. (C) A myelinated axon from an intramuscular nerve at 4 weeks of age showing a cluster of tubulovesicular organelles sequestered by double membranes (arrow). Bar = 500nm.