1. How Can Precision Medicine in Oncology Refine Best Treatment Approach?

2. Introduction

3. How Has Precision Medicine Changed the Treatment Landscape in Oncology?

4. Selection of Biomarkers in Drug Development

5. Methods to Identify Driver Mutations

6. Which Method Should Be Used?

7. Challenges With Testing Methods in Precision Medicine

8. Novel Targets: NTRK

9. Novel Targets

10. Estimated Frequency of TRK Fusions Varies Across Tumor Types

11. Active Clinical Trials of TRK Inhibitors in Patients With NTRK Fusion Tumors

12. Entrectinib Studies

13. Best Response to Entrectinib in Patients With TKI Treatment-Naive Extracranial Solid Tumors

14. Larotrectinib Basket Trials

15. Clinical Efficacy of Larotrectinib in NTRK Fusion Cancers

16. Integrated Clinical Development of Larotrectinib Simultaneously Across Adult and Pediatric Cancers

17. NTRK Testing Options

18. Pan-TRK IHC Staining Concordance With RNA Testing

19. Conclusions

20. Abbreviations

21. Abbreviations (cont)