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Published byΜαριάμ Μαρής Modified over 6 years ago
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How Can Precision Medicine in Oncology Refine Best Treatment Approach?
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Introduction
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How Has Precision Medicine Changed the Treatment Landscape in Oncology?
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Selection of Biomarkers in Drug Development
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Methods to Identify Driver Mutations
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Which Method Should Be Used?
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Challenges With Testing Methods in Precision Medicine
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Novel Targets: NTRK
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Novel Targets
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Estimated Frequency of TRK Fusions Varies Across Tumor Types
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Active Clinical Trials of TRK Inhibitors in Patients With NTRK Fusion Tumors
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Entrectinib Studies
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Best Response to Entrectinib in Patients With TKI Treatment-Naive Extracranial Solid Tumors
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Larotrectinib Basket Trials
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Clinical Efficacy of Larotrectinib in NTRK Fusion Cancers
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Integrated Clinical Development of Larotrectinib Simultaneously Across Adult and Pediatric Cancers
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NTRK Testing Options
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Pan-TRK IHC Staining Concordance With RNA Testing
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Conclusions
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Abbreviations
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Abbreviations (cont)
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