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Severe Chromosomal Aberrations in Pleural Mesotheliomas with Unusual Mesodermal Features  Michael Krismann, Klaus-Michael Müller, Malgorzata Jaworska,

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Presentation on theme: "Severe Chromosomal Aberrations in Pleural Mesotheliomas with Unusual Mesodermal Features  Michael Krismann, Klaus-Michael Müller, Malgorzata Jaworska,"— Presentation transcript:

1 Severe Chromosomal Aberrations in Pleural Mesotheliomas with Unusual Mesodermal Features 
Michael Krismann, Klaus-Michael Müller, Malgorzata Jaworska, Georg Johnen  The Journal of Molecular Diagnostics  Volume 2, Issue 4, Pages (November 2000) DOI: /S (10) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Morphological findings with mesodermomas. A: Pleural mesodermoma, 60-year-old man with a known history of asbestos exposure (case M1). Epithelial follicular tumor area resembling thyroid gland tissue. Thyreoglobulin was not detectable immunohistochemically (H&E). B: Same case as presented in A. Chondroid area of the tumor that was included in the CGH analysis (H&E). Immunohistochemical results. C: Calretinin staining. Heterogeneous staining pattern with positive reaction in the large pleomorphic cells, but negative result in the small cell areas (case M8). D:Smooth muscle actin staining with positive reaction in the small cell portion of the tumor, the stromal cells being negative (case M8). The Journal of Molecular Diagnostics 2000 2, DOI: ( /S (10) ) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 CGH results. Fluorescence ratio profile of case M3a, 66-year-old woman without known history of asbestos exposure. High number of genetic imbalances. Losses are represented as red bars on the left side of each chromosome ideogram, gains are represented as green bars on the right side. The reference DNA was from a male donor. Therefore, the X chromosome shows a gain and the Y chromosome a loss. The Journal of Molecular Diagnostics 2000 2, DOI: ( /S (10) ) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4 Figure 3 Summary of CGH results. Defects are represented in superkaryograms by superposition of all CGH profiles of each tumor group. A:Chromosomal imbalances of eight mesodermomas. B: Chromosomal imbalances of 10 biphasic mesotheliomas. Losses are shown as vertical lines on the left side of a chromosome, gains are shown on the right side. The Journal of Molecular Diagnostics 2000 2, DOI: ( /S (10) ) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

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