1. Evaluation of tablet dosage form 1) weight variation
Aram I. Ibrahim
University of sulaimani
College of pharmacy
Dep. Of pharmaceutics

2. Content
Introduction
Causes of weight variation
Procedure
Limitations

3. Introduction
Weight variations of the tablets produced is a relatively common problem of the tableting process.
Each tableting process aims at producing tablets with a constant weight.

4. Causes of weight variation
The actual cause for this problem is the lack of weighing systems for each single tablet before pressing.
Each tablet press, doses a certain amount of powder into the die and this powder is then pressed. This means that a volume is dosed, not the weight.
Hence, weight variations in a limited extent are quite normal due to variations in the density of the powder material and to a partially incomplete filling of the dies due to poor powder flow.

5. Procedure Take 20 tablets, dedust and weigh individually.
Weigh all 20 tablets together and calculate average weight.
Calculate % deviation for each tablet:

6. Limitations
The tablet pass the U.S.P. test if no more that 2 tablets are out of % limit and if no tablet differs by more than 2 times of % limit.