1. Volume 164, Issue 5, Pages 844-846 (February 2016)
Revisiting Management of Pediatric Brain Tumors with New Molecular Insights 
Wafik Zaky 
Cell 
Volume 164, Issue 5, Pages (February 2016)
DOI: /j.cell
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
New Molecular Classification of CNS-PNETs by DNA Methylation Profiling and the Validated Genetic Aberrations in Each Entity with Its Possible Target Drug(s)
The molecular analyses of Sturm et al. (2016) of 323 CNS-PNET tumors led to a new molecular classification scheme, with some tumor types sharing characteristics with other types of brain tumors and some comprising four genetically defined entities that had not been characterized before. For these, the genetic alternations (noted with an asterisk) have postulated oncogenicity, but further evaluation is required to assess its role in the specified subgroup. Abbreviations: HGG, high grade gliomas; MNG, meningiomas; EPN, ependymomas; ATRT, atypical teratoid rhabdoid tumors; MB, medulloblastoma; PINEAL, pineal tumors; EWS, Ewing sarcomas; CPC, choroid plexus carcinomas; PXA, pleomorphic xanthoastrocytomas; ETMR, embryonal tumors with multi-layered rosettes; NOS, not otherwise specified; TRK, tyrosine receptor kinases; HDAC, histone deacetylase; IGF-IR, insulin like growth factor receptor.
Cell  , DOI: ( /j.cell )
Copyright © 2016 Elsevier Inc. Terms and Conditions