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Plerixafor Plus Granulocyte Colony-Stimulating Factor versus Placebo Plus Granulocyte Colony-Stimulating Factor for Mobilization of CD34+ Hematopoietic.

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Presentation on theme: "Plerixafor Plus Granulocyte Colony-Stimulating Factor versus Placebo Plus Granulocyte Colony-Stimulating Factor for Mobilization of CD34+ Hematopoietic."— Presentation transcript:

1 Plerixafor Plus Granulocyte Colony-Stimulating Factor versus Placebo Plus Granulocyte Colony-Stimulating Factor for Mobilization of CD34+ Hematopoietic Stem Cells in Patients with Multiple Myeloma and Low Peripheral Blood CD34+ Cell Count: Results of a Subset Analysis of a Randomized Trial  Auayporn P. Nademanee, John F. DiPersio, Richard T. Maziarz, Edward A. Stadtmauer, Ivana N. Micallef, Patrick J. Stiff, Frank J. Hsu, Gary Bridger, Brian J. Bolwell  Biology of Blood and Marrow Transplantation  Volume 18, Issue 10, Pages (October 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Stem cell mobilization and collection schemes.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Proportion of patients collecting the minimum stem cell dose (≥2 × 106 CD34+ cells/kg) in 1 day (black), 2 days (black + dark gray), 3 days (black + dark gray + light gray), and 4 days (black + dark gray + light gray + white) of apheresis. Data in the graph are summarized in the table. P values apply to plerixafor versus placebo comparisons for a given cell count group on a given day of apheresis. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Proportion of patients collecting the optimum stem cell dose (≥6 × 106 CD34+ cells/kg) in 1 day (black), 2 days (black + dark gray), 3 days (black + dark gray + light gray), and 4 days (black + dark gray + light gray + white) of apheresis. Data in the graph are summarized in the table. P values apply to comparisons of plerixafor-treated and placebo-treated patients for a given cell count group on a given day of apheresis. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Median cumulative CD34+ cells/kg collected in 1 day (black), 2 days (black + dark gray), 3 days (black + dark gray + light gray), and 4 days (black + dark gray + light gray + white) of apheresis. P < .001 for plerixafor versus placebo in all cell count groups on days 1, 2, and 3 and in the <15 cells/μL, <20 cells/μL, and ≥20 cells/μL groups on day 4; P = .003 for plerixafor versus placebo in the <10 cells/μL group on day 4. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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